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Article Example different places or that are at different dedifferentiation stages are very distinguished in their cell motility (Yamazaki, Kurisu, and Takenawa, 2009). Rho motility is shown in single cancer cells, the amoeboid cells are round and their motility relies on the Rho/ROCK kinase. Mesenchymal motility cells are elongated and bipolar and these cells can also switch to amoeboid motility through treatment with protease inhibitors. Rho cell motility is regulated through the process of cytoskeletal restructuring and some studies have shown them to be deregulated in select tumors. Research has indicated that Rho signaling dictate the round morphology and the motility of the cells in 3D matrices. To fully comprehend and understand cell invasion research must continue to study how the Rho families of proteins are regulated in the cancer cell. In 3D substrates round cells have a higher concentration of RhoA. Several related Rho activated proteins are being shown to inhibit cancer cell growth. Nguyen, Quang-Dà ©, et al. "Commutators of PAR-1 Signaling in Cancer Cell Invasion Reveal an Essential Role of the Rho-Rho Kinase Axis and Tumor Microenvironment."  Oncogene  24.56 (2005): 8240-51.  OxResearch; ProQuest Central.  Web. 10 Dec. 2012. Yamazaki, D., S. Kurisu, and T. Takenawa. "Involvement of Rac and Rho Signaling in Cancer Cell Motility in 3D Substrates."Oncogene  28.13 (2009): 1570-83.  OxResearch; ProQuest Central.  Web. 10 Dec.